[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-α-Neo-Endorphin (1-8) is a synthetic analog of the endogenous opioid peptide α-Neoendorphin, specific全てy engineered with an arginine substitution at position 8 to enhance receptor binding affinity and metabolic stability. This octapeptide retains the core Tyr-Gly-Gly-Phe opioid motif, 全てowing it to interact potently with κ-opioid receptors (KOR) and μ-opioid receptors (MOR) in the central nervous system. It is primarily utilized in biochemical re検索 as a stable tool compound for investigating pain pathways, stress responses, and the structure-activity relationships (SAR) of dynorphin-derived peptides.



TECHNICAL SPECIFICATIONS


Item
Specification
製品 名前
[Arg8]-a-Neo-Endorphin (1-8)
CAS NO.
75106-72-8
Appearance
White to off-white lyophilized powder
Molecular Formula
C₄₆H₇₃N₁₅O₁₀
Molecular Weight
1036.2g/mol
Purity (RP-HPLC)
≥98% 
Solubility

Soluble in 1M acetic acid, DMSO, or deionized water

Endotoxin
≤1 EU/mg 
Biological Activity
Potent agonist for κ-opioid receptors (KOR)
Storage Conditions
Store at -20°C, protected from light and moisture
Stock 位置
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

The peptide functions as a potent agonist at G protein-coupled opioid receptors, with a pronounced preference for the κ-opioid receptor (KOR) subtype. Upon binding, it inhibits adenylate cyclase activity, reducing intracellular cAMP levels and leading to neuronal hyperpolarization via the opening of potassium channels. This mechanism effectively suppresses neurotransmitter release (e.g., glutamate and substance P) in pain-processing pathways, resulting in antinociceptive and potential dysphoric effects characteristic of KOR activation.

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2.製品 INDICATIONS

This 製品 is strictly for Re検索 Use Only (RUO) and is indicated for in vitro and preclinical studies targeting the opioid system. It is ideal for scientists in neuropharmacology and drug discovery who require a stable, high-affinity ligand for receptor binding assays, functional cAMP accumulation tests, and animal model studies of analgesia. The [Arg8] modification makes it particularly suitable for experiments requiring enhanced enzymatic stability compared to the native peptide sequence.

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3.CLINICAL EFFICACY OF 製品

As a re検索 chemical, [Arg8]-α-Neo-Endorphin (1-8) is not intended for human therapeutic use and has no approved clinical efficacy data. In experimental settings, this analog demonstrates superior and prolonged analgesic efficacy in rodent models of inflammatory and neuropathic pain compared to unmodified fragments. Its enhanced stability translates to longer-lasting behavioral effects, providing robust preclinical data for the development of novel opioid-based therapeutics.

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4.証明書

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide 製品, adhering strictly to quality standards and obtaining internation全てy recognized 認証s.


私たちの製品ion partners 全て employ GMP-compliant 製品ion systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of 製品 comes with complete documentation, including a 証明書 of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and re検索-grade peptide 製品 to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging 解決 to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the 製品.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the 製品ion and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The 会社 invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA 認証s, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality 製品 and superior services.


We focus on the re検索 and development and supply of high-quality chemical 製品, strictly adhering to international standards and quality systems. 私たちの製品s are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific re検索, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


Hot タグ: Arg8AlphaNeoEndorphin, #AlphaNeoEndorphinAnalog, #OpioidPeptide, #KappaOpioidReceptorAgonist, #KORAgonist, #DynorphinSystem, #PainRe検索Peptide, #NeuropharmacologyReagent, #SyntheticOpioid, #Re検索Chemical, #PeptideAgonist, #AnalgesiaRe検索, #ReceptorBindingAssay, #NeuroscienceTool, #BiochemicalReagent, #RUO

If you have any 製品 requirements, please 送信 an メール to:support@huanqiukeji9.com;whatsapp:85244969439

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